The best selling console games always seem to be sports-related. WWE, TNA, UFC, NFL/Madden, NBA, NHL, MLB, FIFA/soccer, Olympics, racing/NASCAR/Grand Theft Auto, and Flight Simulators.
Mutant League Football is a video game that was released in 1993 for the Sega Genesis. The game was designed using the Madden '93 engine, and features a different take on football, where the games resemble a war as much as a sporting competition.
Quarterback s a 2-player football arcade game released by Leland in 1987.
I still have one of those green handheld Electronic Football games from 1977. I showed it to a 14-year-old friend of mine recently and (after he figured it out) he thought it was the coolest thing ever.